Editorial II: Which anaesthetic agent for maintenance during normothermic cardiopulmonary bypass?

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Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery.

PURPOSE To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery. METHODS Twenty patients in two equal groups were studied. Anaesthesia was induced with sufentanil and midazolam after a standard premedication. Doxacurium was administered at 3 x ED95 (80 micrograms.kg-1), and ...

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Normothermic Cardiopulmonary Bypass in the Larger Patient

____________ _ A 27 -year-old male patient presented for elective arrythmia surgery. Due to the nature of the surgical procedure, i.e. normothermic bypass, light anaesthetic, dislocation of the heart, etc., the physical size of this patient was of concern. The patient was 183 em tall and weighed 141 kg. The calculated body surface area was 2.68 M2 and the calculated flow was 6.7 LPM. Because of...

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Glucose homeostasis. Comparison between hypothermic and normothermic cardiopulmonary bypass.

STUDY OBJECTIVE Disturbance in blood glucose homeostasis during cardiac surgery may cause visceral and metabolic alterations. Hypothermic CPB induces glucose and hormonal changes. As normothermic CPB is used at some institutions, a comparison of blood glucose and plasma hormones between hypothermic and normothermic CPB was performed. DESIGN Prospective nonrandomized study. SETTING Universit...

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Plasma propofol concentration and EEG burst suppression ratio during normothermic cardiopulmonary bypass.

BACKGROUND During cardiopulmonary bypass (CPB), several factors affect drug disposition and action. This topic has not been studied extensively during normothermic CPB. In this study, we related propofol dose to plasma propofol concentration and burst suppression of the EEG during normothermic bypass. METHODS After institutional approval and informed consent, 45 patients having cardiac surger...

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Plasma proteomic changes during hypothermic and normothermic cardiopulmonary bypass in aortic surgeries

Deep hypothermic circulatory arrest (DHCA) is a protective method against brain ischemia in aortic surgery. However, the possible effects of DHCA on the plasma proteins remain to be determined. In the present study, we used novel high‑throughput technology to compare the plasma proteomes during DHCA (22˚C) with selective cerebral perfusion (SCP, n=7) to those during normothermic cardiopulmonary...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 2003

ISSN: 0007-0912,1471-6771

DOI: 10.1093/bja/aeg027